Comparative anti-glycation and alpha-glucosidase inhibition studies of microbial transformed compounds of dydrogesterone

Anti-glycation and alpha-glucosidase inhibition activities of microbial transformed compounds of dydrogesterone [1]; 20R-hydroxy-9 beta,10 alpha-pregna-4,6-diene-3-one [2], 17 beta-hydroxy-9 beta,10 alpha-androsta-4,6-diene-3-one [3] and 9 beta,10 alpha- androsta-4,6-diene-3,17-dione [4] were evaluated. Compounds 1 and 4 showed potent alpha-glucosidase inhibitory activities, while 2 and 3 were found to be weak inhibitors, whereas anti-glycation activities of 1-4 were not observed

Role of early soft tissue coverage and bone grafting in management of grade-III-B musculoskeletel trauma-experience of 30 cases

The present study is a review of 30 cases of grade-III B Musculoskeletal trauma treated at Bolan Medical Complex Hospital, Quetta. The patient with grade-Ill B Musculoskeletal injury needs soft tissue coverage and bone grafting. The purpose of study was to find out rate of infection, as well as non-union, and functional compromise after early or late re-construction of soft tissue coverage and bone grafting in grade-III B open fractures of bone. Rotational fascio-cuteneous myofascio cutenious or relaxing incision was used for coverage of bear bone. Thirty cases were scheduled each case was properly follow up for a period of six months to two year. The potential benefit of soft tissue coverage and bone grafting is time related. Experience with thirty patients shows that there is significant decrease in rate of infection as well as non-union in patient who had soft tissue coverage and bone grafting within one to two weeks time after the injury, Importance of time factor has been emphasized

Acetylcholinesterase and butyrylcholinesterase inhibitory potential of some Pakistani medicinal plants

The crude extracts of some selected Pakistani medicinal plants, namely, Acacia modesta, Buddleja crispa. Carthamus oxycantha, Conyza bonariensis and Tanacetum artemisioides were assessed for their inhibitory activities against acetylcholinesterase [AChE] and butyrylcholinesterase [BChE]. All the tested plant extracts exhibited dose dependent [0.25 - 1.0 mg/ml] inhibitory effects against both these enzymes with more selectivity for BChE. A. modesta and C. bonariensis showed activity against BChE only. The plant extracts of B. crispa C. oxycantha and T. artemisioides caused maximum inhibition of AChE at 1.0 mg/ml with% inhibition of 28, 34 and 48 respectively. In the BChE inhibitory evaluation all the tested plant extracts at 1.0 mg/ml produced marked inhibition [68-80%] of the enzyme activity. The results show the presence of selective BChE inhibitory constituents in the aforementioned plant extracts

1-D and 2D-NMR assignments of nigricin from iris imbricata

Ethanolic crude extract of I. imbricata Lindl. [Iridaceae] was subjected to column chromatography on silica gel with varying portions of MeOH: CHCl[3]. Nigicin [irisolone] was isolated and its identification carried out by IR, UV, MS, 1-D and 2-D NMR spectroscopy